Best Cancer Surgeon in PCMC | Best Cancer Specialist in PCMC | Does Smoking Weed Cause Lung Cancer? Smoking weed may introduce similar carcinogens into the lungs as tobacco, which can potentially cause respiratory issues over time. While research on the link between marijuana use and lung cancer is inconclusive, smoking any kind of substance can irritate lung tissues. Although cannabis users tend to smoke less frequently than tobacco users, inhaling smoke from marijuana still exposes the lungs to harmful substances. It's important to be aware of the potential long-term effects of smoking weed on lung health. Consult with a healthcare professional for personalized advice.